HAPIN Trial

Research suggests that household air pollution exposure experienced during gestation and early life is linked to a range of longer-term outcomes, and that the benefits of reduced exposure may continue even after the intervention ends. We therefore conducted an extended follow-up study, continuing to follow HAPIN children at 3 of the 4 research sites (Guatemala, India and Rwanda) through age 5, to evaluate the effects of the original HAPIN intervention on neurologic and physical development. This follow-up study was funded by the National Institute of Environmental Health Sciences, and was entitled "Assessing the 5-Year Effects of a 500-day Liquefied Petroleum Gas Cooking Intervention: Continued Follow-up of Participants from the HAPIN trial". 

The work built on the major investment already made in the trial, leveraging a well-characterized cohort in 3 diverse settings and carried out by experienced field teams with strong, ongoing relationships with participants. Participant follow-up ended in June 2025, and data analysis and manuscript writing is ongoing.